Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria
نویسندگان
چکیده
منابع مشابه
Targeting of Endothelial Activation in Cerebral Malaria
Malaria is one of the most serious of all tropical parasitic diseases: a severe and life-threatening form of which in humans is cerebral malaria, a complication that can occur in malaria caused by Plasmodium falciparum. This grave complication involves malarial infection of the red blood cells that accumulate within the very small capillaries that fl ow through the tissues of the brain. Even wh...
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Cerebral malaria is the most common cause of non-traumatic encephalopathy in the world. The mainstay of therapy is either quinine or artemisinin, both of which are effective antimalarials. The clinical picture of cerebral malaria may persist or even become worse in spite of the clearance of parasites from blood. The death rate is unacceptably high even with effective antimalarials in tertiary c...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1801737115